The episode follows a crew of sleazy space miners - two sexist men and one large, manly woman - who contract a gender-changing and ultimately fatal virus which they then unwittingly share with the crew of the Lexx. While the disease does not affect the external appearance, it changes the genitals and the voice and works on the mind, making men extremely demure and making women into voracious sexual predators. In this episode Stanley Tweedle finally fulfills his dream of having sex with his crewmate Xev Bellringer, although it is arguably more of a **** and during the encounter their genders are reversed.