Mesothelioma- Can it be caused by smoking? Get the Mesothelioma smoking facts, Los Angeles area residents. Mesothelioma is a disease, the only known cause of which is Asbestos exposure. If you or someone you know has been exposed to Asbestos, its important to tell your doctor. The cause of Mesothelioma is not smoking. Get the facts in this video, and learn more at our website.