F1 - the amazing one-off six wheel Tyrrell P34. Driven by Patrick Depailler this special car was a Ken Tyrell innovation. So as to provide as small a surface to the air as possible (frontal area). To do this, Tyrrell designer Derek Gardner started by reducing the diameter of the front wheels to just 10 inches (25cm) so they could be tucked completely behind a front fairing.
To my surprise it was not the first 6-wheel racing car.
Web info: http://www.f1nutter.co.uk/tech/6wheels.php