More than 100 years have past since the battle between Jonathan Joestar and the vampire, Dio Brando. Now Dio's escape from the ocean depths awakens the psychic power known as "Stand" within 17-year-old Jotaro "JoJo" Kujo and his grandfather Josef Joestar. Now they must battle the immortal vampire Dio, who holds Jotaro's mother Holley prisoner in a nightmare-filled coma. But they're not alone. Joining them in their quest are four warriors who also posses mystical Stand powers. These powers are manifested in giant spectral warriors that emerge from the bodies of the group. But Dio has gathered Stand warriors as well, and he possesses a secret and incredibly powerful Stand of his own.