In episode 52 of MicrobeWorld Video, filmed at the American Association for the Advancement of Science Meeting in Washington, D.C., on February 18, 2011, Dr. Stan Maloy talks with Diane Harper, M.D., M.P.H, Professor in the departments of Community and Family Medicine, Obstetrics and Gynecology, and Informatics and Personalized Health at the University of Missouri-Kansas City. Harper played a critical role in the clinical studies associated with the HPV vaccines and has voiced concerns over their long term ability to prevent cancer. She and Maloy discuss these concerns, gender differences in protection, and the challenges of creating a pan HPV vaccine.