St. Joseph, MOSt. Joseph, MO, is one of the most historically significant places in the country. It was the last major hub before early settlers headed out to expand West. Enriched with beautiful archetecture, much of the downtown areas buildings and districts are in the National Register of Historic Places. There are distinct museums to visit, all with its unique character. The Pony Express began, Jesse James met his demise, and Lewis and Clark played a significant role here. Relive history, visit St. Joseph.